Interactions between ddavp(desmopressin) and Carbamazepine extended release (carbamazepine)
carbamazepine and desmopressin (Moderate Drug-Drug)
MONITOR: The use of selective serotonin reuptake inhibitors (SSRIs) has rarely been associated with hyponatremia, sometimes secondary to development of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). These events have generally been reversible following discontinuation of SSRI therapy and/or medical intervention. SSRI-related hyponatremia may be more common in elderly female patients and those who are volume-depleted or receiving concomitant diuretic therapy. Other drugs, including tricyclic antidepressants, chlorpromazine, chlorpropamide, carbamazepine, and nonsteroidal anti-inflammatory agents (NSAIDS), may also potentiate the effects of DDAVP and increase the risk of water intoxication and hyponatremia.
MANAGEMENT: Caution may be warranted during concomitant use. Serum electrolytes, especially sodium as well as BUN and plasma creatinine, should be monitored regularly.
