darifenacin and Adrenocot Interactions

Interactions between darifenacin and Adrenocot (dexamethasone)

dexamethasone and darifenacin (Moderate Drug-Drug)

MONITOR: Theoretically, coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of darifenacin, which has been shown to be a substrate of the isoenzyme.

MANAGEMENT: Pharmacologic response to darifenacin should be monitored more closely whenever a CYP450 3A4 inducer is added to or withdrawn from therapy, and the darifenacin dosage adjusted if necessary.