danocrine and Buprenex Interactions

Interactions between danocrine(danazol) and Buprenex (buprenorphine)

danazol and buprenorphine (Moderate Drug-Drug)

MONITOR: Coadministration with drugs that are inhibitors of the CYP450 3A4 isoenzyme may increase the plasma concentrations and pharmacologic effects of buprenorphine, which is metabolized in the liver by CYP450 3A4. The risk of central nervous system and respiratory depression may be increased.

MANAGEMENT: Pharmacologic response to buprenorphine and vital signs should be monitored more closely whenever a CYP450 3A4 inhibitor is added to or withdrawn from therapy, and the buprenorphine dosage adjusted as necessary. If clinically significant respiratory depression occurs, buprenorphine should be withdrawn.