danocrine and Bexarotene Interactions

Interactions between danocrine(danazol) and Bexarotene (bexarotene)

danazol and bexarotene (Moderate Drug-Drug)

MONITOR: Bexarotene serum concentrations may be increased when administered concomitantly with drugs that are inhibitors of the CYP450 3A4 enzyme system. Bexarotene is a substrate of CYP450 3A4 in vitro.

MANAGEMENT: The patient should be observed for clinical and laboratory evidence of altered safety and efficacy of bexarotene if a drug that inhibits CYP450 3A4 is added to or removed from the patient's medication regimen. Patients should be advised to notify their physician if they experience persistent nausea, vomiting, diarrhea, weakness, back pain, headache, or other unusual symptoms.