cytotec and Ex lax milk of magnesia Interactions

You searched for interactions between

• cytotec (misoprostol)
• Ex lax milk of magnesia (magnesium hydroxide)

Interaction(s) found:

misoprostol and magnesium hydroxide (Moderate Drug-Drug)

GENERALLY AVOID: Magnesium-containing antacids can exacerbate misoprostol-induced diarrhea. Additionally, antacids in general can reduce the bioavailability of misoprostol acid (the active metabolite of misoprostol), although clinical trials of misoprostol conducted with concomitant antacid use suggest that this effect is not clinically important.

MANAGEMENT: Use of misoprostol in combination with magnesium-containing antacids is not recommended. If an antacid is needed, one that contains aluminum or calcium should be prescribed.