cytotec and Cal oys Interactions

You searched for interactions between

• cytotec (misoprostol)
• Cal oys (calcium carbonate)

Interaction(s) found:

misoprostol and calcium carbonate (Minor Drug-Drug)

Concomitant administration of antacids can reduce the bioavailability of misoprostol acid, the active metabolite of misoprostol. The mechanism of interaction is unknown. In twelve study subjects, coadministration of misoprostol with antacid reduced the bioavailability of misoprostol acid by 16% relative to fasting. Clinical trials of misoprostol conducted with concomitant antacid use suggest that this effect is not clinically important.