cytadren and Anisindione Interactions

Interactions between cytadren(aminoglutethimide) and Anisindione (anisindione)

anisindione and aminoglutethimide (Moderate Drug-Drug)

MONITOR: Aminoglutethimide may significantly increase warfarin clearance by induction of CYP450 2C9 and/or 3A4 hepatic microsomal enzymes. In one study, warfarin clearance increased three- to fivefold. A similar effect may occur with other oral anticoagulants.

MANAGEMENT: The patient should be monitored for reduced anticoagulant effect when aminoglutethimide is added, discontinued, or the dosage is changed. Patients should be advised to promptly report any signs of blood clots (e.g. chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity).