cytadren and Aminophylline extended release Interactions

Interactions between cytadren(aminoglutethimide) and Aminophylline extended release (aminophylline)

aminoglutethimide and aminophylline (Moderate Drug-Drug)

MONITOR: Aminoglutethimide may significantly reduce theophylline serum concentrations by increasing theophylline clearance. The mechanism is induction of CYP450 3A4 hepatic microsomal enzymes. One study noted an increase of 32% in theophylline clearance. Conversely, theophylline toxicity may occur after aminoglutethimide is discontinued.

MANAGEMENT: The patient should be monitored for clinical and laboratory evidence of altered theophylline response when aminoglutethimide is added, discontinued, or the dosage is changed. Patients should be advised to notify their physician if they experience a worsening of their respiratory symptoms during concurrent therapy.