Drug interactions between cyproheptadine and Zoloft
Results for the following 2 drugs: |
|
|---|---|
| cyproheptadine | |
| Zoloft (sertraline) | |
Interactions between your selected drugs
cyproheptadine ⇔ sertraline
Applies to: cyproheptadine and Zoloft (sertraline)
MONITOR: Serotonin antagonists such as cyproheptadine and methysergide may diminish the pharmacologic effects of selective serotonin reuptake inhibitors (SSRIs) and other highly serotonergic agents (e.g., 5-hydroxytryptophan). This pharmacodynamic interaction is sometimes exploited in the use of cyproheptadine and methysergide for the treatment of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 2A receptors. Theoretically, serotonergic agents may also antagonize the pharmacologic effects of cyproheptadine and methysergide, although this effect has not been reported.
MANAGEMENT: Patients should be monitored for potentially diminished therapeutic response to serotonergic agents during coadministration with cyproheptadine or methysergide, and dosages adjusted as necessary.
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