Drug interactions between Cymbalta and Nexium
Results for the following 2 drugs: |
|
|---|---|
| Cymbalta (duloxetine) | |
| Nexium (esomeprazole) | |
Interactions between your selected drugs
esomeprazole ⇔ duloxetine
Applies to: Nexium (esomeprazole) and Cymbalta (duloxetine)
Coadministration of enteric-coated duloxetine with substances that raise gastrointestinal pH may result in earlier release of duloxetine from the formulation. The enteric coating is intended to resist drug dissolution until reaching a segment of the gastrointestinal tract where the pH exceeds 5.5. However, coadministration with aluminum- and magnesium-containing antacids (51 mEq) or famotidine has been shown to have no significant effect on the rate or extent of duloxetine absorption following administration of a 40 mg oral dose. It is unknown whether concomitant administration of proton pump inhibitors would affect duloxetine absorption.
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