cyclosporine and Foscavir Interactions

Interactions between cyclosporine(cycloSPORINE) and Foscavir (foscarnet)

foscarnet and cycloSPORINE (Major Drug-Drug)

GENERALLY AVOID: Renal failure risk may be increased in patients on foscarnet and cyclosporine therapy. The mechanism may be due to additive or synergistic nephrotoxicity. In two reported cases, cyclosporine concentrations remained within the therapeutic range and renal function returned to normal after discontinuation of the foscarnet.

MANAGEMENT: The manufacturer recommends avoiding the concurrent use of other nephrotoxic drugs during foscarnet therapy. If these agents are used concomitantly, consider close observation of renal function and discontinue foscarnet treatment if needed.