Drug interactions between cyclophosphamide and Miradon
| Results for the following 2 drugs: |
|---|
| cyclophosphamide |
| Miradon (anisindione) |
Interactions between your selected drugs
cyclophosphamide ↔ anisindione
Applies to:cyclophosphamide and Miradon (anisindione)
MONITOR: Cyclophosphamide may increase or decrease the anticoagulant activity of warfarin by an unknown mechanism. Since, in some cases, the anticoagulant effect of warfarin has markedly increased after cyclophosphamide has been discontinued, some experts have speculated that cyclophosphamide stimulates the hepatic metabolism of warfarin. According to this suggestion, discontinuing cyclophosphamide could decrease metabolism, increase plasma levels, and increase the anticoagulant effect of warfarin. Other oral anticoagulants may interact with cyclophosphamide in a similar manner.
MANAGEMENT: Careful monitoring of the INR during coadministration and after discontinuation is recommended. Patients should be advised to promptly report any signs of bleeding (e.g., pain, swelling, headache, dizziness, weakness, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools) or blood clots (e.g. chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity).
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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