Drug interactions between Crestor and warfarin
Results for the following 2 drugs: |
|
|---|---|
| Crestor (rosuvastatin) | |
| warfarin | |
Interactions between your selected drugs
warfarin ⇔ rosuvastatin
Applies to: warfarin and Crestor (rosuvastatin)
MONITOR: Rosuvastatin may enhance the hypoprothrombinemic effect of warfarin and other oral anticoagulants. According to the product labeling, administration of rosuvastatin to patients stabilized on warfarin resulted in clinically significant rises in the INR (greater than 4, baseline 2 to 3). The mechanism of interaction is unknown. Coadministration of rosuvastatin 40 mg and warfarin 20 mg did not alter the plasma concentrations of warfarin.
MANAGEMENT: Caution is recommended if rosuvastatin is used concomitantly with oral anticoagulants. The INR should be checked frequently and anticoagulant dosage adjusted accordingly, particularly following initiation, discontinuation or change of dosage of rosuvastatin in patients who are stabilized on their anticoagulant regimen. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.
See also...
Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. Multum's drug information does not endorse drugs, diagnose patients, or recommend therapy. Multum's drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2009 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.
