Drug interactions between Coumadin and Medrol
Results for the following 2 drugs: |
|
|---|---|
| Coumadin (warfarin) | |
| Medrol (methylprednisolone) | |
Interactions between your selected drugs
warfarin ⇔ methylprednisolone
Applies to: Coumadin (warfarin) and Medrol (methylprednisolone)
MONITOR: Corticosteroids and adrenocorticotropic agents may alter the pharmacologic effects of oral anticoagulants. Both increased anticoagulant dosage requirements as well as bleeding and increased anticoagulant sensitivity have been reported during concomitant corticosteroid therapy. Proposed mechanisms include blood hypercoagulability or diminished vascular integrity induced by corticosteroids. Conversely, the risk of gastrointestinal bleeding associated with the ulcerogenic effect of corticosteroids may be potentiated by use of oral anticoagulants.
MANAGEMENT: Patients should be monitored for clinical and laboratory evidence of increased or decreased anticoagulant response during concurrent treatment with corticosteroids or adrenocorticotropic agents. They should be advised to promptly report any signs and symptoms of bleeding (e.g., pain, swelling, headache, dizziness, weakness, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools) or of blood clots (e.g., chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity).
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