Drug interactions between Coumadin and heparin
Results for the following 2 drugs: |
|
|---|---|
| Coumadin (warfarin) | |
| heparin | |
Interactions between your selected drugs
warfarin ⇔ heparin
Applies to: Coumadin (warfarin) and heparin
MONITOR CLOSELY: Although therapy with heparin and oral anticoagulants often overlap in clinical practice, the potential for additive anticoagulant effects and increased risk of severe bleeding should be considered. Oral anticoagulants may prolong the activated partial thromboplastin time (aPTT) in patients receiving heparin, while heparin may prolong the International Normalized Ratio (INR) in patients receiving warfarin.
MANAGEMENT: During concurrent or overlapping therapy, close clinical and laboratory observation for hematologic complications is recommended. To minimize the interference of heparin on INR determinations, blood should not be drawn until at least 5 hours after the last intravenous heparin dose or 24 hours after the last subcutaneous heparin dose.
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