colistimethate and Anectine Interactions

You searched for interactions between

• colistimethate
• Anectine (succinylcholine)

Interaction(s) found:

succinylcholine and colistimethate (Moderate Drug-Drug)

MONITOR: Like other polypeptide antibiotics, colistimethate may prolong apnea and respiratory paralysis after use of neuromuscular blocking agents. The mechanism may be related to decreased intracellular potassium or decreased ionized serum calcium. (Intravenous calcium administration has been reported to be helpful in reversing paralysis caused by polymyxin B in some cases.)

MANAGEMENT: Patients should be closely monitored for prolonged neuromuscular blockade.