colestipol and Chlorothiazide Interactions

You searched for interactions between

• colestipol
• Chlorothiazide (chlorothiazide)

Interaction(s) found:

chlorothiazide and colestipol (Moderate Drug-Drug)

ADJUST DOSING INTERVAL: Colestipol may decrease the absorption of the thiazide diuretics. Diuretic effect may be reduced. The mechanism is believed to be thiazide binding by the anion-exchange resin in the intestine, resulting in decreased plasma levels and decreased urinary excretion of thiazides. This interaction has been reported in clinical studies with chlorothiazide and hydrochlorothiazide.

MANAGEMENT: Thiazide diuretics should be administered as far apart from colestipol as possible, but at least one hour before or four hours after colestipol. Patients should be monitored for loss of diuretic effect and electrolyte imbalances.