Drug interactions between colesevelam and Miradon
| Results for the following 2 drugs: |
|---|
| colesevelam |
| Miradon (anisindione) |
Interactions between your selected drugs
anisindione ↔ colesevelam
Applies to:Miradon (anisindione) and colesevelam
MONITOR: Decreases in International Normalized Ratio (INR) have been reported during postmarketing use of colesevelam in patients receiving warfarin. The mechanism of interaction is unknown. In an in vivo drug interaction study, colesevelam had no effect on warfarin bioavailability during coadministration. However, the study did not evaluate warfarin pharmacodynamics.
MONITOR: Bile acid sequestrants can decrease the absorption of fat-soluble vitamins like vitamin K. No specific studies have been conducted to evaluate potential effects of colesevelam on the absorption of coadministered dietary or supplemental vitamins. In non-clinical safety studies, rats administered colesevelam at doses greater than 30-fold the projected human clinical dose developed hemorrhage in association with vitamin K deficiency.
MANAGEMENT: Patients receiving warfarin and other oral anticoagulants should have their INR monitored before initiating colesevelam and frequently during early colesevelam therapy.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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