Drug interactions between codeine/phenylephrine/promethazine and Viagra
| Results for the following 2 drugs: |
|---|
| codeine/phenylephrine/promethazine |
| Viagra (sildenafil) |
Interactions between your selected drugs
codeine ↔ sildenafil
Applies to:codeine/phenylephrine/promethazine and Viagra (sildenafil)
MONITOR: Acute intake of opiates during sildenafil use may result in prolonged erections. The proposed mechanism is an opiate-induced acute increase in cyclic guanosine monophosphate concentrations in peripheral nerve endings, which can be additive with that produced by sildenafil. The interaction has been reported specifically with dihydrocodeine but could conceivably occur with other opiates. In two patients who had been using sildenafil for erectile dysfunction, prolonged erections lasting 2 to 5 hours occurred on several occasions of sildenafil use within the first week after initiation of treatment with dihydrocodeine. One patient discontinued the dihydrocodeine, whereupon his erections from sildenafil returned to normal. The other patient continued taking dihydrocodeine for an additional 2 weeks but had no further problems.
MANAGEMENT: Patients using sildenafil should be advised of the potential for prolonged erections during acute intake of opiates, and to contact their physician if problems occur. The interaction may not occur during chronic use of opiates.
See also...
- Codeine/phenylephrine/promethazine Drug Interactions
- codeine, phenylephrine, and promethazine General Consumer Information
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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