Drug interactions between Co-trimoxazole and valganciclovir
Results for the following 2 drugs: |
|
|---|---|
| Co-trimoxazole (sulfamethoxazole/trimethoprim) | |
| valganciclovir | |
Interactions between your selected drugs
trimethoprim ⇔ valganciclovir
Applies to: Co-trimoxazole (sulfamethoxazole/trimethoprim) and valganciclovir
The coadministration of ganciclovir or its prodrug, valganciclovir, with trimethoprim may result in elevated plasma concentrations of ganciclovir. In 12 subjects with HIV and CMV coinfection, trimethoprim (200 mg orally once a day) increased the half-life of ganciclovir (1000 mg orally every 8 hours) by an average of 15% and decreased its renal clearance by 16%. The mechanism is unknown but may involve the competitive inhibition of ganciclovir renal tubular secretion by trimethoprim. Ganciclovir had minimal effect on the pharmacokinetics of trimethoprim. This interaction is unlikely to be of clinical significance.
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