Drug interactions between clozapine and Lamictal
Results for the following 2 drugs: |
|
|---|---|
| clozapine | |
| Lamictal (lamotrigine) | |
Interactions between your selected drugs
clozapine ⇔ lamotrigine
Applies to: clozapine and Lamictal (lamotrigine)
MONITOR: A case report suggests that lamotrigine may increase the plasma concentrations of clozapine. The mechanism of interaction and a causal relationship have not been established. In the report, a 35-year-old man who had been stabilized on clozapine 400 mg/day for three years developed dizziness and sedation in association with a threefold increase in clozapine plasma concentration after two weeks of taking lamotrigine 100 mg/day. The dosage of lamotrigine was tapered over the next two weeks, and plasma clozapine levels returned to therapeutic levels.
MANAGEMENT: Pharmacologic response and plasma clozapine levels should be monitored more closely whenever lamotrigine is added to or withdrawn from therapy, and the clozapine dosage adjusted as necessary.
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