Drug interactions between clozapine and Lamictal
| Results for the following 2 drugs: |
|---|
| clozapine |
| Lamictal (lamotrigine) |
Interactions between your selected drugs
clozapine ↔ lamotrigine
Applies to:clozapine and Lamictal (lamotrigine)
MONITOR: A case report suggests that lamotrigine may increase the plasma concentrations of clozapine. The mechanism of interaction and a causal relationship have not been established. In the report, a 35-year-old man who had been stabilized on clozapine 400 mg/day for three years developed dizziness and sedation in association with a threefold increase in clozapine plasma concentration after two weeks of taking lamotrigine 100 mg/day. The dosage of lamotrigine was tapered over the next two weeks, and plasma clozapine levels returned to therapeutic levels.
MANAGEMENT: Pharmacologic response and plasma clozapine levels should be monitored more closely whenever lamotrigine is added to or withdrawn from therapy, and the clozapine dosage adjusted as necessary.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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