Drug interactions between clonidine and Sandimmune
| Results for the following 2 drugs: |
|---|
| clonidine |
| Sandimmune (cyclosporine) |
Interactions between your selected drugs
clonidine ↔ cyclosporine
Applies to:clonidine and Sandimmune (cyclosporine)
MONITOR: A single case has been reported in which whole-blood cyclosporine levels rose significantly and abruptly after the addition of clonidine and decreased after discontinuation of clonidine. Transdermal clonidine has also been associated with increases in cyclosporine levels. The mechanism is unknown. In addition, it has been suggested that clonidine may have a beneficial effect in preventing cyclosporine-induced nephrotoxicity. The mechanism is unknown and data have been conflicting.
MANAGEMENT: Until more information is available, frequent monitoring of whole-blood cyclosporine levels and renal function is recommended. Patients should be advised to notify their physician if they experience symptoms of possible cyclosporine toxicity, such as nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, or headache.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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