clonazepam and Amobarbital Interactions

Interactions between clonazepam and Amobarbital (amobarbital)

amobarbital and clonazepam (Moderate Drug-Drug)

MONITOR: Barbiturates may increase the plasma clearance of clonazepam and thereby reduce its clinical effectiveness. Phenobarbital is the only barbiturate specifically implicated in this interaction. However, other barbiturates may behave in a similar fashion. Also, clonazepam may increase the effectiveness of barbiturates. A case of respiratory depression and coma has been reported in a patient receiving high doses of both clonazepam and amobarbital.

MANAGEMENT: If these drugs are used together, close observation for altered clonazepam and barbiturate effects is indicated.