cleocin-hcl and Erythromycin stearate Interactions

Interactions between cleocin-hcl(clindamycin) and Erythromycin stearate (erythromycin)

clindamycin and erythromycin (Moderate Drug-Drug)

GENERALLY AVOID: Lincomycin derivatives and erythromycin have antagonistic effects in vitro. The mechanism is competitive binding of the 50S ribosomal subunit.

MANAGEMENT: Clindamycin or lincomycin should not be used concurrently with erythromycin.