Drug interactions between Claritin and Sporanox
Results for the following 2 drugs: |
|
|---|---|
| Claritin (loratadine) | |
| Sporanox (itraconazole) | |
Interactions between your selected drugs
itraconazole ⇔ loratadine
Applies to: Sporanox (itraconazole) and Claritin (loratadine)
Ketoconazole has been reported to inhibit the metabolism of loratadine. Area under the plasma concentration time curve (AUC) has increased 180% for loratadine and 56% for its active metabolite. The mechanism of this interaction is inhibition of CYP450 3A4 metabolism by ketoconazole. No adverse effects or cardiotoxicity were observed in this study. Loratadine and cetirizine appear to be safe for use with ketoconazole. Terfenadine and astemizole should not be used with ketoconazole.
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