Drug interactions between citalopram and Fragmin
| Results for the following 2 drugs: |
|---|
| citalopram |
| Fragmin (dalteparin) |
Interactions between your selected drugs
dalteparin ↔ citalopram
Applies to:Fragmin (dalteparin) and citalopram
MONITOR: Serotonin reuptake inhibitors may potentiate the risk of bleeding in patients receiving heparin therapy. The exact mechanism is unknown but may involve a pharmacodynamic interaction, as serotonin reuptake inhibitors have been reported to interfere with platelet function. A case of abdominal bleeding was reported in an elderly patient who had been treated with fluoxetine for over a year and tinzaparin for 5 days prior to hospital admission. A potential drug interaction as well as accumulation of tinzaparin secondary to impaired renal function were suspected as the cause of bleeding.
MANAGEMENT: Caution is recommended if a serotonin reuptake inhibitor is administered with heparin therapy, especially in the elderly and patients with renal impairment. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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