Drug interactions between Cipro XR and metoprolol
Results for the following 2 drugs: |
|
|---|---|
| Cipro XR (ciprofloxacin) | |
| metoprolol | |
Interactions between your selected drugs
ciprofloxacin ⇔ metoprolol
Applies to: Cipro XR (ciprofloxacin) and metoprolol
The coadministration of ciprofloxacin and metoprolol may result in elevated plasma concentrations of the latter. In seven healthy male subjects, ciprofloxacin (500 mg orally every 12 hours for 5 doses) increased the area under the plasma concentration-time curve (AUC) of a single oral dose of metoprolol (100 mg) by 54% for its less active (+) enantiomer and 29% for its more active (-) enantiomer. The oral clearance of (+) and (-) metoprolol was decreased by 38.5% and 12.5%, respectively. The mechanism by which ciprofloxacin may increase metoprolol plasma concentrations is unknown. Ciprofloxacin has not been shown to inhibit the CYP450 2D6 isoenzyme, which is responsible for the metabolism of metoprolol and several other beta-blockers. Since pharmacodynamic effects were not described in the study, the clinical significance of the interaction is also unclear. Until further data are available, it may be appropriate to monitor patients for potentially increased pharmacologic effects of metoprolol during concomitant therapy with ciprofloxacin. Patients should be advised to notify their physician if they experience possible symptoms of increased beta blockade such as fainting, swelling of the extremities, weight gain, or slow pulse.
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