Drug interactions between cimetidine and Percocet
Results for the following 2 drugs: |
|
|---|---|
| cimetidine | |
| Percocet (acetaminophen/oxycodone) | |
Interactions between your selected drugs
cimetidine ⇔ oxycodone
Applies to: cimetidine and Percocet (acetaminophen/oxycodone)
MONITOR: Cimetidine may increase the action of narcotic analgesics. Cases of respiratory depression and apnea have been reported. The mechanism is unknown.
MANAGEMENT: Patients' vital signs should be closely monitored while receiving this combination. If clinically significant respiratory depression occurs, the drugs should be withdrawn. The use of a narcotic antagonist, such as naloxone, may be needed.
acetaminophen ⇔ cimetidine
Applies to: Percocet (acetaminophen/oxycodone) and cimetidine
Animal studies and some limited human studies have suggested that cimetidine may decrease the potential hepatotoxic effects of acetaminophen. The mechanism may be related to reductions in the rate at which reactive intermediate metabolites are formed. Not all studies have confirmed the occurrence of this interaction. No alterations in dosage are necessary.
See also...
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