Drug interactions between cimetidine and Lexapro
Results for the following 2 drugs: |
|
|---|---|
| cimetidine | |
| Lexapro (escitalopram) | |
Interactions between your selected drugs
cimetidine ⇔ escitalopram
Applies to: cimetidine and Lexapro (escitalopram)
MONITOR: The coadministration with cimetidine may increase the serum concentrations of the selective serotonin reuptake inhibitors, or SSRIs, citalopram (racemic) and escitalopram (the more pharmacologically active s-enantiomer). The proposed mechanism is cimetidine inhibition of CYP450 2C19 and 3A4, the isoenzymes responsible for the metabolic clearance of these SSRIs. In a crossover study consisting of 12 healthy subjects, cimetidine (400 mg orally twice a day for 8 days) increased the steady-state peak serum concentration (Cmax) and area under the concentration-time curve (AUC) of citalopram (40 mg orally once a day) by 39% and 43%, respectively. The clinical significance of these changes is unknown, and data are not available for escitalopram.
MANAGEMENT: Pharmacologic response to citalopram or escitalopram should be monitored more closely whenever cimetidine is added to or withdrawn from therapy, and the SSRI dosage adjusted as necessary. Alternatively, other H2-receptor antagonists such as famotidine, nizatidine, and ranitidine may be considered, since they are unlikely to interfere with the metabolism of citalopram and escitalopram.
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