Drug interactions between cholestyramine and Lipitor
Results for the following 2 drugs: |
|
|---|---|
| cholestyramine | |
| Lipitor (atorvastatin) | |
Interactions between your selected drugs
cholestyramine ⇔ atorvastatin
Applies to: cholestyramine and Lipitor (atorvastatin)
ADJUST DOSING INTERVAL: When administered concomitantly, cholestyramine has been reported to decrease the rate and extent of fluvastatin bioavailability. Other bile acid sequestrants may also decrease the bioavailability of other HMG-CoA reductase inhibitors. The mechanism of action is most likely due to adsorption of the HMG-CoA reductase inhibitor to the bile acid sequestrant. Separating administration times has been shown to decrease the interaction.
MANAGEMENT: If therapy with both agents is necessary, the HMG-CoA reductase inhibitor should be administered at least 4 hours after the bile acid sequestrant.
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