Drug interactions between Cholestyramine Light and Lasix
| Results for the following 2 drugs: |
|---|
| Cholestyramine Light (cholestyramine) |
| Lasix (furosemide) |
Interactions between your selected drugs
furosemide ↔ cholestyramine
Applies to:Lasix (furosemide) and Cholestyramine Light (cholestyramine)
ADJUST DOSING INTERVAL: Limited data have shown that the bioavailability of orally administered furosemide is reduced by 95% during concurrent administration of cholestyramine and by 80% during concurrent administration of colestipol. (These figures are based on data from the area under the plasma concentration-time curve and total urinary elimination data.) These decreases in bioavailability were associated with 77% and 58% reductions in the diuretic response to furosemide. No data are available for bumetanide, torsemide, or ethacrynic acid, but a similar interaction is suspected.
MANAGEMENT: Diuretics should be administered at least 2 to 3 hours before cholestyramine or colestipol. If alternating dosage schedules is ineffective, it may be necessary to increase diuretic dosage during coadministration. Patients should be monitored for altered diuretic efficacy.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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