Drug interactions between Cholestyramine Light and Inderide
| Results for the following 2 drugs: |
|---|
| Cholestyramine Light (cholestyramine) |
| Inderide (hydrochlorothiazide/propranolol) |
Interactions between your selected drugs
cholestyramine ↔ hydrochlorothiazide
Applies to:Cholestyramine Light (cholestyramine) and Inderide (hydrochlorothiazide/propranolol)
ADJUST DOSING INTERVAL: Cholestyramine may significantly decrease the absorption of hydrochlorothiazide by binding with it in the gut.
MANAGEMENT: Hydrochlorothiazide should be administered at least four to six hours after cholestyramine. Patients should be monitored for altered efficacy because absorption may still be reduced, even with separation of doses.
propranolol ↔ cholestyramine
Applies to:Inderide (hydrochlorothiazide/propranolol) and Cholestyramine Light (cholestyramine)
Limited data suggest that cholestyramine may decrease the absorption of propranolol, possibly reducing its pharmacologic effect. The clinical significance is unknown and data have been conflicting. Studies with single doses reported decreased propranolol plasma levels but no significant changes in blood pressure or pulse rate. One study found no change in propranolol absorption.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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