chlorzoxazone and Antabuse Interactions

Interactions between chlorzoxazone and Antabuse (disulfiram)

chlorzoxazone and disulfiram (Moderate Drug-Drug)

MONITOR: Disulfiram may increase the depressant effects that chlorzoxazone has on the central nervous system. The mechanism is inhibition of the CYP450 2E1 hepatic metabolism of chlorzoxazone, resulting in increased serum levels and half-life.

MANAGEMENT: Patients should be monitored for excessive CNS depressant effects. If these effects increase during concomitant administration, the clinician should consider decreasing chlorzoxazone dosage. Patients should be advised to report excessive sedation, headache or nausea to their physician.