Drug interactions between chloroquine and Tagamet
| Results for the following 2 drugs: |
|---|
| chloroquine |
| Tagamet (cimetidine) |
Interactions between your selected drugs
chloroquine ↔ cimetidine
Applies to:chloroquine and Tagamet (cimetidine)
GENERALLY AVOID: The coadministration with cimetidine may increase the plasma concentrations of oral chloroquine. The proposed mechanism cimetidine inhibition of chloroquine metabolism via cytochrome P450 isoenzymes. In five healthy volunteers, pretreatment with cimetidine (400 mg at bedtime for four days) resulted in a 53% decrease in the apparent oral clearance of chloroquine (600 mg base), a 49% increase in its elimination half-life, and a 57% increase in apparent volume of distribution relative to five healthy volunteers given chloroquine alone. There was also a 47% reduction in the area under the plasma concentration-time curve of the major metabolite, monodesethylchloroquine, in cimetidine subjects compared to controls.
MANAGEMENT: The concomitant use of chloroquine and cimetidine should be avoided. Other H2-receptor antagonists such as famotidine, nizatidine, and ranitidine may be considered, since they are unlikely to interfere with cytochrome P450 metabolism.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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