Drug interactions between Chloromycetin and Glucotrol
| Results for the following 2 drugs: |
|---|
| Chloromycetin (chloramphenicol) |
| Glucotrol (glipizide) |
Interactions between your selected drugs
chloramphenicol ↔ glipizide
Applies to:Chloromycetin (chloramphenicol) and Glucotrol (glipizide)
MONITOR: The concomitant use of chloramphenicol and oral sulfonylureas may result in an enhanced hypoglycemic effect. The proposed mechanism is reduced hepatic clearance of sulfonylureas, or displacement of sulfonylureas from protein binding sites.
MANAGEMENT: Patients should be monitored for hypoglycemia when chloramphenicol is added to a sulfonylurea regimen, and for hyperglycemia when chloramphenicol is discontinued. The sulfonylurea dosage may require adjustment in affected patients. Patients receiving this combination should be advised to regularly monitor their blood sugar, counseled on how to recognize and treat hypoglycemia (e.g., headache, dizziness, drowsiness, nausea, tremor, hunger, weakness, or palpitations) and to notify their physician if it occurs.
See also...
- Chloromycetin Drug Interactions
- Chloromycetin Oral, Intravenous, Injection General Consumer Information
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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