chlordiazepoxide and Clozaril Interactions

Interactions between chlordiazepoxide and Clozaril (clozapine)

chlordiazepoxide and clozapine (Major Drug-Drug)

MONITOR CLOSELY: Benzodiazepines and clozapine may have additive effects on respiratory and cardiovascular function. Ataxia, excessive salivation, hypotension, collapse, respiratory depression, respiratory arrest, loss of consciousness, cardiac arrest, and sudden death have been reported. The mechanism is unknown and causality has not been clearly determined.

MANAGEMENT: Caution is advised if concurrent therapy is necessary. Vital signs should be closely monitored.