Drug interactions between Chemdal Expectorant and Unisom SleepMelts
| Results for the following 2 drugs: |
|---|
| Chemdal Expectorant (codeine/guaifenesin/phenylpropanolamine) |
| Unisom SleepMelts (diphenhydramine) |
Interactions between your selected drugs
codeine ↔ diphenhydramine
Applies to:Chemdal Expectorant (codeine/guaifenesin/phenylpropanolamine) and Unisom SleepMelts (diphenhydramine)
MONITOR: Drugs that are inhibitors of CYP450 2D6 may interfere with the analgesic effect of codeine. The mechanism is decreased in vivo conversion of codeine to morphine, a metabolic reaction mediated by CYP450 2D6.
MANAGEMENT: The possibility of reduced or inadequate pain relief should be considered in patients receiving codeine with drugs that inhibit CYP450 2D6. An increase in the codeine dosage or a different analgesic agent may be necessary in patients requiring therapy with CYP450 2D6 inhibitors.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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