charcoal-plus-ds and Arava Interactions

Interactions between charcoal-plus-ds(charcoal) and Arava (leflunomide)

charcoal and leflunomide (Moderate Drug-Drug)

GENERALLY AVOID: A significant decrease in M1, the active metabolite of leflunomide, has resulted when cholestyramine or activated charcoal is administered to patients receiving leflunomide. Administration of cholestyramine 8 grams 3 times a day has resulted in a 40% decrease in plasma levels of M1 in a 24 hour period.

MANAGEMENT: Coadministration of these drugs is not recommended.