cerezyme and Zavesca Interactions

Interactions between cerezyme(imiglucerase) and Zavesca (miglustat)

imiglucerase and miglustat (Moderate Drug-Drug)

GENERALLY AVOID: Coadministration with miglustat may increase the clearance of imiglucerase. The mechanism of interaction has not been described. In patients stabilized on imiglucerase 7.5 or 15 units/kg/day, coadministration with miglustat 100 mg orally three times a day for one month appeared to increase the clearance of imiglucerase by 70%, although the results are not conclusive due to the small number of subjects studied and the variable doses of imiglucerase administered. Imiglucerase had no significant effect on the pharmacokinetics of miglustat.

MANAGEMENT: Miglustat labeling states that use with imiglucerase is not indicated.