Drug interactions between Celebrex and pimozide
Results for the following 2 drugs: |
|
|---|---|
| Celebrex (celecoxib) | |
| pimozide | |
Interactions between your selected drugs
pimozide ⇔ celecoxib
Applies to: pimozide and Celebrex (celecoxib)
CONTRAINDICATED: Coadministration with inhibitors of CYP450 2D6 may increase the plasma concentrations of pimozide, which is partially metabolized by the isoenzyme. In a controlled study of healthy volunteers, administration of pimozide (2 mg single dose) with the potent inhibitor paroxetine (60 mg daily) resulted in mean increases of 62% and 151% in pimozide peak plasma concentration (Cmax) and systemic exposure (AUC), respectively, compared to pimozide given alone. Quinidine, another potent inhibitor of CYP450 2D6, has been shown in vitro to also inhibit the metabolism of pimozide. The use of pimozide has been associated with dose-related prolongation of the QT interval, thus elevated plasma levels of the drug may potentiate the risk of ventricular arrhythmias such as ventricular tachycardia and torsade de pointes as well as cardiac arrest and sudden death. MANAGEMENT: Due to the narrow therapeutic index of pimozide, the manufacturers consider its use with CYP450 2D6 inhibitors to be contraindicated.
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