casodex and Coumadin Interactions

Interactions between casodex(bicalutamide) and Coumadin (warfarin)

warfarin and bicalutamide (Minor Drug-Drug)

In vitro studies have shown that bicalutamide can displace coumarin anticoagulants such as warfarin from protein-binding sites, theoretically resulting in enhanced anticoagulant effects. PT should be monitored closely when bicalutamide is initiated in patients already receiving coumarin anticoagulants. The anticoagulant dosage should be adjusted as needed. Patients should be advised to notify their physicians if they experience any signs of excessive anticoagulation, such as unusual or prolonged bleeding, bruising, vomiting, change in stool or urine color, headache, dizziness, or weakness.