Drug interactions between Cardizem and Celexa
Results for the following 2 drugs: |
|
|---|---|
| Cardizem (diltiazem) | |
| Celexa (citalopram) | |
Interactions between your selected drugs
diltiazem ⇔ citalopram
Applies to: Cardizem (diltiazem) and Celexa (citalopram)
MONITOR: The coadministration with drugs that are inhibitors of the CYP450 3A4 enzymatic pathway may increase the plasma concentrations of citalopram, which is partially metabolized by CYP450 3A4. While clinical data are lacking, the possibility of increased pharmacological effects and/or serotonin syndrome should be considered.
MANAGEMENT: Dosage adjustments as well as clinical and laboratory monitoring may be appropriate whenever an enzyme inhibitor is added to or withdrawn from therapy. Close monitoring is recommended for signs and symptoms of excessive serotonergic activity such as CNS irritability, altered consciousness, confusion, myoclonus, ataxia, abdominal cramping, hyperpyrexia, shivering, pupillary dilation, diaphoresis, hypertension, and tachycardia.
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