Drug interactions between Carbatrol and Vitamin D
Results for the following 2 drugs: |
|
|---|---|
| Carbatrol (carbamazepine) | |
| Vitamin D (ergocalciferol) | |
Interactions between your selected drugs
carbamazepine ⇔ ergocalciferol
Applies to: Carbatrol (carbamazepine) and Vitamin D (ergocalciferol)
MONITOR: Coadministration with CYP450 inducers such as rifampin, isoniazid, barbiturates, and certain anticonvulsants may decrease the pharmacologic effects of vitamin D analogs. These agents are thought to induce the hepatic conversion of vitamin D to inactive metabolites and have been shown to reduce circulating levels of active vitamin D, sometimes accompanied by reduced serum calcium and increased parathyroid hormone levels. Patients on long-term anticonvulsant therapy have occasionally developed osteomalacia, presumably due to interference with vitamin D and calcium metabolism. There have also been isolated reports of patients who responded poorly to vitamin D supplements during treatment with phenytoin and/or primidone.
MANAGEMENT: Patients receiving vitamin D analogs with CYP450 inducers should be monitored for potentially reduced vitamin D effects. Dosage adjustments may be necessary.
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