Drug interactions between Canasa and warfarin
Results for the following 2 drugs: |
|
|---|---|
| Canasa (mesalamine) | |
| warfarin | |
Interactions between your selected drugs
warfarin ⇔ mesalamine
Applies to: warfarin and Canasa (mesalamine)
MONITOR: A case has been reported of a likely interaction between warfarin and mesalamine resulting in failure to attain the hypoprothrombinemic effect of warfarin. The mechanism of this interaction is unknown. The clinician who reported this interaction speculated that mesalamine may have complexed with warfarin, preventing warfarin's intestinal absorption or metabolism. Whether rectally administered mesalamine may interfere with absorption is unclear. Data on other oral anticoagulants are lacking.
MANAGEMENT: Until more information is available, clinicians should closely monitor prothrombin time if an anticoagulant and mesalamine are administered concurrently. Patients should be advised to promptly report any signs of blood clots (e.g. chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity).
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