Drug interactions between calcium carbonate and Ultrase
| Results for the following 2 drugs: |
|---|
| calcium carbonate |
| Ultrase (pancrelipase) |
Interactions between your selected drugs
calcium carbonate ↔ pancrelipase
Applies to:calcium carbonate and Ultrase (pancrelipase)
GENERALLY AVOID: Coadministration with the combination of calcium carbonate and magnesium hydroxide may reduce the therapeutic effects of pancrelipase in the treatment of steatorrhea. The mechanism involves precipitation of glycine-conjugated bile acids and formation of calcium and magnesium fatty acid soaps, resulting in a decrease in fat absorption. In addition, by increasing gastric pH, antacids may reduce the resistance of the enteric coating of some formulations of pancreatic enzymes, resulting in earlier release and destruction of enzymatic activity.
MANAGEMENT: Patients receiving pancrelipase for steatorrhea should avoid taking the medication together with a combination of calcium carbonate and magnesium hydroxide. Calcium carbonate and magnesium hydroxide may be found in certain antacids, and calcium carbonate may also be found in certain calcium or mineral supplements.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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