Drug interactions between Calcium 600 D and sodium polystyrene sulfonate
| Results for the following 2 drugs: |
|---|
| Calcium 600 D (calcium/vitamin d) |
| sodium polystyrene sulfonate |
Interactions between your selected drugs
calcium carbonate ↔ sodium polystyrene sulfonate
Applies to:Calcium 600 D (calcium/vitamin d) and sodium polystyrene sulfonate
GENERALLY AVOID: Systemic alkalosis has been reported when cation-exchange resins were administered orally in combination with nonabsorbable cation-donating preparations such as antacids or laxatives. The mechanism involves binding of the cation to the resin, which prevents the cation from neutralizing bicarbonate ions in the intestine and also interferes with the resin's potassium exchange capability. This interaction may be more likely and more severe in patients with renal dysfunction. Other serious adverse effects have also been reported. One patient with chronic hypocalcemia of renal failure developed alkalosis and grand mal seizure when given sodium polystyrene sulfonate with magnesium hydroxide as a laxative. Intestinal obstruction due to concretions of aluminum hydroxide has occurred in combination with sodium polystyrene sulfonate.
MANAGEMENT: Nonabsorbable calcium, magnesium, or aluminum preparations such as antacids or laxatives should not be used in patients receiving oral cation-exchange resins. Alternatively, the interaction may be avoided by administering the resin as an enema.
See also...
- Sodium polystyrene sulfonate Drug Interactions
- Pms-Sodium Polystyrene Sulfonate General Consumer Information
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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