Drug interactions between Calcium 600 D and levofloxacin
Results for the following 2 drugs: |
|
|---|---|
| Calcium 600 D (calcium/vitamin d) | |
| levofloxacin | |
Interactions between your selected drugs
calcium carbonate ⇔ levofloxacin
Applies to: Calcium 600 D (calcium/vitamin d) and levofloxacin
ADJUST DOSING INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics. Absorption may also be reduced by sucralfate, which contains aluminum, as well as other polyvalent cations such as iron and zinc. The mechanism is chelation of quinolones by polyvalent cations, forming a complex that is poorly absorbed from the gastrointestinal tract. The bioavailability of ciprofloxacin has been reported to decrease by as much as 90% when administered with antacids containing aluminum or magnesium hydroxide.
MANAGEMENT: When coadministration cannot be avoided, quinolone antibiotics should be dosed either 2 to 4 hours before or 4 to 6 hours after polyvalent cation-containing products to minimize the potential for interaction.
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