calcarb and Alendronate Interactions

Interactions between calcarb(calcium carbonate) and Alendronate (alendronate)

calcium carbonate and alendronate (Moderate Drug-Drug)

ADJUST DOSING INTERVAL: Products containing calcium and other polyvalent cations such as antacids are likely to interfere with the gastrointestinal absorption of oral bisphosphonates. The bioavailability of tiludronate has been shown to decrease 80% during simultaneous administration with calcium, and 60% when aluminum- or magnesium-containing antacids were administered one hour before tiludronate.

MANAGEMENT: Oral medications containing antacids (e.g., didanosine buffered tablets or pediatric oral solution), calcium, and other polyvalent cations should be administered at least 30 minutes after the bisphosphonate dose. The manufacturers of etidronate and tiludronate recommend an interval of at least 2 hours. Calcium supplements may be taken at least 2 hours before or 2 hours after etidronate or tiludronate.