Interactions between caffeine and Cymbalta (duloxetine)
caffeine and duloxetine (Moderate Drug-Drug)
MONITOR: Coadministration with drugs that are inhibitors of CYP450 1A2 may increase the plasma concentrations of duloxetine, which is partially metabolized by the isoenzyme. According to the product labeling for duloxetine, coadministration with fluvoxamine, a potent CYP450 1A2 inhibitor, resulted in a 2.5-fold increase in peak plasma concentration (Cmax), a 5-fold increase in systemic exposure (AUC), and a 3-fold increase in half-life of duloxetine in 14 male subjects. Other drugs that inhibit CYP450 1A2 metabolism include cimetidine, isoniazid, mexiletine, zileuton.
MANAGEMENT: Caution is advised if duloxetine is used with CYP450 1A2 inhibitors. Pharmacologic response to duloxetine should be monitored more closely whenever a CYP450 1A2 inhibitor is added to or withdrawn from therapy.
