Caffeine Drug Interactions
Currently displaying all 82 drugs (403 brand and generic names) known to interact with caffeine.
See also: The most common drugs checked in combination with this medicine.
Medications known to interact with caffeine
Jump to: A B C D E F G H I L M N O P Q R S T U V Y Z
acetaminophen / aluminum hydroxide / aspirin / caffeine / magnesium hydroxide
acetaminophen / aspirin
acetaminophen / aspirin / caffeine
acetaminophen / aspirin / caffeine / salicylamide
acetaminophen / aspirin / phenylpropanolamine
Acetylsalicylic Acid (aspirin)
Acuprin 81 (aspirin)
Adeno-jec (adenosine)
Adenocard (adenosine)
Adenoscan (adenosine)
adenosine
Adult Strength (aspirin / caffeine)
Aerolate III (theophylline)
Aerolate JR (theophylline)
Aerolate SR (theophylline)
Aggrenox (aspirin / dipyridamole)
Agrylin (anagrelide)
Alka-Seltzer Extra Strength (aspirin / citric acid / sodium bicarbonate)
Alka-Seltzer Lemon-Lime (aspirin / citric acid / sodium bicarbonate)
Alka-Seltzer Original (aspirin / citric acid / sodium bicarbonate)
Alka-Seltzer Plus Cold Formula (aspirin / chlorpheniramine / phenylephrine)
Alka-Seltzer Plus Flu Formula (old formulation) (aspirin / chlorpheniramine / dextromethorphan)
Alka-Seltzer PM (aspirin / diphenhydramine)
Alka-Seltzer Wake-Up Call! (aspirin / caffeine)
Alor 5 / 500 (aspirin / hydrocodone)
alosetron
aluminum hydroxide / aspirin / calcium carbonate / magnesium hydroxide
Ami-rax (ephedrine / hydroxyzine / theophylline)
Anacin (aspirin / caffeine)
Anacin Advanced Headache Formula (acetaminophen / aspirin / caffeine)
Anacin Max Strength (aspirin / caffeine)
anagrelide
Antabuse (disulfiram)
Aquaphyllin (theophylline)
Arthritis Foundation Pain Reliever (aspirin)
Arthritis Pain (aspirin)
Arthritis Pain Formula (aluminum hydroxide / aspirin / calcium carbonate / magnesium hydroxide)
Asbron G (guaifenesin / theophylline)
Ascomp with Codeine (aspirin / butalbital / caffeine / codeine)
Ascriptin (aluminum hydroxide / aspirin / calcium carbonate / magnesium hydroxide)
Ascriptin Enteric (aspirin)
Ascriptin Maximum Strength (aluminum hydroxide / aspirin / calcium carbonate / magnesium hydroxide)
asenapine
Asmalix (theophylline)
Aspergum (aspirin)
Aspir 81 (aspirin)
Aspir-Low (aspirin)
Aspir-Mox (aluminum hydroxide / aspirin / calcium carbonate / magnesium hydroxide)
Aspir-Mox IB (aluminum hydroxide / aspirin / calcium carbonate / magnesium hydroxide)
Aspircaf (aspirin / caffeine)
aspirin
Aspirin Buffered (aluminum hydroxide / aspirin / calcium carbonate / magnesium hydroxide)
Aspirin Lite Coat (aspirin)
Aspirin Low Strength (aspirin)
aspirin / brompheniramine / dextromethorphan / phenylpropanolamine
aspirin / butalbital
aspirin / butalbital / caffeine
aspirin / butalbital / caffeine / codeine
aspirin / caffeine
aspirin / caffeine / dihydrocodeine
aspirin / caffeine / orphenadrine
aspirin / caffeine / propoxyphene
aspirin / caffeine / salicylamide
aspirin / calcium carbonate
aspirin / carisoprodol
aspirin / carisoprodol / codeine
aspirin / chlorpheniramine / dextromethorphan
aspirin / chlorpheniramine / dextromethorphan / phenylpropanolamine
aspirin / chlorpheniramine / phenylephrine
aspirin / chlorpheniramine / phenylpropanolamine
aspirin / citric acid / sodium bicarbonate
aspirin / codeine
aspirin / diphenhydramine
aspirin / diphenhydramine / phenylpropanolamine
aspirin / dipyridamole
aspirin / hydrocodone
aspirin / meprobamate
aspirin / methocarbamol
aspirin / oxycodone
aspirin / pentazocine
aspirin / phenyltoloxamine
aspirin / pravastatin
aspirin / pseudoephedrine
Aspiritab (aspirin)
Aspirtab (aspirin)
atazanavir
Azdone (aspirin / hydrocodone)
Azilect (rasagiline)
azithromycin / trovafloxacin
B C Powder (aspirin / caffeine / salicylamide)
B C Powder Arthritis Strength (aspirin / caffeine / salicylamide)
Backaid Inflammatory Pain Formula (acetaminophen / aspirin / caffeine)
Bayer Advanced Aspirin (aspirin)
Bayer AM (aspirin / caffeine)
Bayer Aspirin (aspirin)
Bayer Aspirin Extra Strength Plus (aspirin)
Bayer Aspirin Regimen (aspirin)
Bayer Aspirin with Heart Advantage (aspirin)
Bayer Children's Aspirin (aspirin)
Bayer Extra Strength Back & Body (aspirin / caffeine)
Bayer Headache Relief (aspirin / caffeine)
Bayer PM (aspirin / diphenhydramine)
Bayer Women's Aspirin With Calcium (aspirin)
Bayer Women's Low Dose Plus Calcium (aspirin / calcium carbonate)
BC (aspirin / caffeine)
BC Arthritis (aspirin / caffeine)
BC Fast Pain Relief (aspirin / caffeine / salicylamide)
BC Headache (aspirin / caffeine / salicylamide)
bendamustine
Bio-Melatonin (melatonin)
Blowfish for Hangovers (aspirin / caffeine)
Bronchial (guaifenesin / theophylline)
Broncodur (guaifenesin / theophylline)
Broncomar GG (guaifenesin / theophylline)
Bronkodyl (theophylline)
Buffasal (aspirin)
Buffered Aspirin (aspirin)
Bufferin (aspirin)
Bufferin Arthritis Strength (aspirin)
Bufferin Extra Strength (aspirin)
Bufferin Low Dose (aspirin)
Buffex (aspirin)
Butalbital Compound (aspirin / butalbital / caffeine)
Carisoprodol Compound (aspirin / carisoprodol)
cimetidine
Cipro (ciprofloxacin)
Cipro Cystitis Pack (ciprofloxacin)
Cipro I.V. (ciprofloxacin)
Cipro XR (ciprofloxacin)
ciprofloxacin
Clopine (clozapine)
clozapine
Clozapine Synthon (clozapine)
Clozaril (clozapine)
Commit (nicotine)
ConRx Pain Reliever (acetaminophen / aspirin / caffeine)
Constant-T (theophylline)
Cope (aspirin / caffeine)
CVS Extra Strength Headache Relief (acetaminophen / aspirin / caffeine)
Cymbalta (duloxetine)
Damason-P (aspirin / hydrocodone)
Darvon Compound 32 (aspirin / caffeine / propoxyphene)
Darvon Compound-65 (aspirin / caffeine / propoxyphene)
deferasirox
Delta-Lutin (hydroxyprogesterone)
Denzapine (clozapine)
Diastat (diazepam)
Diastat AcuDial (diazepam)
Diastat Pediatric (diazepam)
diazepam
Diazepam Intensol (diazepam)
dipyridamole
disulfiram
Dizac (diazepam)
duloxetine
Duralutin (hydroxyprogesterone)
Easprin (aspirin)
Ecotrin (aspirin)
Ecotrin Adult Low Strength (aspirin)
Ecotrin Maximum Strength (aspirin)
Ecpirin (aspirin)
Ed-Bron G (guaifenesin / theophylline)
Effervescent Pain Relief (aspirin / citric acid / sodium bicarbonate)
Elixophyllin (theophylline)
Elixophyllin GG (guaifenesin / theophylline)
Elixophyllin KI (potassium iodide / theophylline)
Emagrin (aspirin / caffeine / salicylamide)
Empirin (aspirin)
Empirin with Codeine (aspirin / codeine)
Endodan (aspirin / oxycodone)
enoxacin
Entaprin (aspirin)
Entercote (aspirin)
ephedrine / guaifenesin / theophylline
ephedrine / hydroxyzine / theophylline
ephedrine / phenobarbital / potassium iodide / theophylline
ephedrine / phenobarbital / theophylline
Equagesic (aspirin / meprobamate)
Equaline Acid Reducer (cimetidine)
Equibron G (guaifenesin / theophylline)
Eskalith (lithium)
Eskalith-CR (lithium)
Exaprin (acetaminophen / aspirin / caffeine / salicylamide)
Excedrin (acetaminophen / aspirin / caffeine)
Excedrin Back & Body (acetaminophen / aspirin)
Excedrin Extra Strength (acetaminophen / aspirin / caffeine)
Excedrin Menstrual Complete (acetaminophen / aspirin / caffeine)
Excedrin Migraine (acetaminophen / aspirin / caffeine)
Exjade (deferasirox)
Extra Strength Bayer (aspirin)
Farbital (aspirin / butalbital / caffeine)
Fasprin (aspirin)
FazaClo (clozapine)
fentanyl / ropivacaine
Fiorinal (aspirin / butalbital / caffeine)
Fiorinal with Codeine (aspirin / butalbital / caffeine / codeine)
Fiorinal with Codeine III (aspirin / butalbital / caffeine / codeine)
Fiormor (aspirin / butalbital / caffeine)
Fiortal (aspirin / butalbital / caffeine)
Fiortal with Codeine (aspirin / butalbital / caffeine / codeine)
fluvoxamine
Folex PFS (methotrexate)
Fortabs (aspirin / butalbital / caffeine)
Genace (acetaminophen / aspirin / caffeine)
Genacote (aspirin)
Genasan (aspirin / caffeine)
Gennin-FC (aspirin)
Genprin (aspirin)
Glyceryl T (guaifenesin / theophylline)
Goody's Body Pain (acetaminophen / aspirin)
Goody's Extra Strength (acetaminophen / aspirin / caffeine)
Goody's Extra-Strength Headache Powders (acetaminophen / aspirin / caffeine)
Goody's Headache Powders (acetaminophen / aspirin / caffeine)
grepafloxacin
guaifenesin / theophylline
Habitrol (nicotine)
Halfprin (aspirin)
Health Aid Melatonin (melatonin)
Heartline (aspirin)
Hycamtin (topotecan)
Hydrophed (ephedrine / hydroxyzine / theophylline)
Hydroxy Compound (ephedrine / hydroxyzine / theophylline)
hydroxyprogesterone
Hylutin (hydroxyprogesterone)
Hyprogesterone (hydroxyprogesterone)
Laniroif (aspirin / butalbital / caffeine)
Leader Nicotine Polacrilex (nicotine)
Levacet (acetaminophen / aspirin / caffeine / salicylamide)
Lexiscan (regadenoson)
Litecoat Aspirin (aspirin)
lithium
Lithobid (lithium)
Lithonate (lithium)
Lithotabs (lithium)
Lortab ASA (aspirin / hydrocodone)
Lotronex (alosetron)
Low Dose ASA (aspirin)
Luvox (fluvoxamine)
Luvox CR (fluvoxamine)
Magnaprin (aluminum hydroxide / aspirin / calcium carbonate / magnesium hydroxide)
Makena (hydroxyprogesterone)
Marax (ephedrine / hydroxyzine / theophylline)
Marax DF (ephedrine / hydroxyzine / theophylline)
Medi-Seltzer (aspirin)
Medique Medi-Seltzer (aspirin / citric acid / sodium bicarbonate)
Medique Pain-Off (acetaminophen / aspirin / caffeine)
melatonin
Melatonin Time Release (melatonin)
methotrexate
Methotrexate LPF Sodium (methotrexate)
mibefradil
Micrainin (aspirin / meprobamate)
Midol Traditional (aspirin / caffeine)
Migralex (aspirin)
Minitabs (aspirin)
Mintezol (thiabendazole)
Momentum (aspirin / phenyltoloxamine)
My-O-Den (adenosine)
nalidixic acid
Naropin (ropivacaine)
Naropin Novaplus (ropivacaine)
Naropin Polyamp (ropivacaine)
Naropin SDV (ropivacaine)
NegGram (nalidixic acid)
Nicoderm CQ (nicotine)
Nicorelief (nicotine)
Nicorette (nicotine)
Nicorette DS (nicotine)
nicotine
Nicotrol Inhaler (nicotine)
Nicotrol NS (nicotine)
Nicotrol TD (nicotine)
norfloxacin
Norgesic (aspirin / caffeine / orphenadrine)
Norgesic Forte (aspirin / caffeine / orphenadrine)
Noroxin (norfloxacin)
Norwich Aspirin (aspirin)
Orap (pimozide)
Orphengesic (aspirin / caffeine / orphenadrine)
Orphengesic Forte (aspirin / caffeine / orphenadrine)
P-A-C (aspirin / caffeine)
P-A-C Analgesic (aspirin / caffeine)
Painaid (acetaminophen / aspirin / caffeine / salicylamide)
PainAid Extra-Strength Formula (acetaminophen / aspirin / caffeine)
Pamprin Max Menstrual Pain Relief (acetaminophen / aspirin / caffeine)
Panasal 5 / 500 (aspirin / hydrocodone)
PC-CAP (aspirin / caffeine / propoxyphene)
Penetrex (enoxacin)
Percodan (aspirin / oxycodone)
Percodan-Demi (aspirin / oxycodone)
Persantine (dipyridamole)
Persantine IV (dipyridamole)
pimozide
Posicor (mibefradil)
potassium iodide / theophylline
Pravigard Pac (aspirin / pravastatin)
Primatene Dual Action (ephedrine / guaifenesin / theophylline)
Prodrox (hydroxyprogesterone)
Propoxyphene Compound 65 (aspirin / caffeine / propoxyphene)
Proquin XR (ciprofloxacin)
ProStep (nicotine)
Q-B (guaifenesin / theophylline)
Quadrinal (ephedrine / phenobarbital / potassium iodide / theophylline)
Quibron (guaifenesin / theophylline)
Quibron 300 (guaifenesin / theophylline)
Quibron-T (theophylline)
Quibron-T / SR (theophylline)
rasagiline
Raxar (grepafloxacin)
regadenoson
Repreve (ropinirole)
Requip (ropinirole)
ReQuip Follow on Pack (ropinirole)
Requip Starter Kit (ropinirole)
ReQuip Starter Pack (ropinirole)
Requip XL (ropinirole)
Respbid (theophylline)
Reyataz (atazanavir)
Rheumatrex Dose Pack (methotrexate)
Rhinocaps (acetaminophen / aspirin / phenylpropanolamine)
Rilutek (riluzole)
riluzole
Robaxisal (aspirin / methocarbamol)
ropinirole
ropivacaine
ropivacaine / sufentanil
Roxiprin (aspirin / oxycodone)
Saleto (acetaminophen / aspirin / caffeine / salicylamide)
Saphris (asenapine)
SGard (melatonin)
Slo-Bid Gyrocaps (theophylline)
Slo-Phyllin (theophylline)
Slo-Phyllin 125 (theophylline)
Slo-Phyllin 80 (theophylline)
Slo-Phyllin GG (guaifenesin / theophylline)
Sloprin (aspirin)
Solu-Phyllin GG (guaifenesin / theophylline)
Soma Compound (aspirin / carisoprodol)
Soma Compound with Codeine (aspirin / carisoprodol / codeine)
St. Joseph 81 mg Aspirin Enteric Safety-Coated (aspirin)
St. Joseph 81 mg Chewable Aspirin (aspirin)
St. Joseph Aspirin (aspirin)
Stanback (aspirin / caffeine)
Stanback Analgesic (aspirin)
Stanback Fast Pain Relief (aspirin / caffeine / salicylamide)
Supac (acetaminophen / aspirin / caffeine)
Synalgos-DC (aspirin / caffeine / dihydrocodeine)
T-Phyl (theophylline)
Tagamet (cimetidine)
Tagamet HB (cimetidine)
Talwin Compound (aspirin / pentazocine)
Tedrigen (ephedrine / phenobarbital / theophylline)
Theo G (guaifenesin / theophylline)
Theo-24 (theophylline)
Theo-Dur (theophylline)
Theo-Dur Sprinkles (theophylline)
Theo-Time (theophylline)
Theo-X (theophylline)
Theobid (theophylline)
TheoCap (theophylline)
Theochron (theophylline)
Theoclear LA-130 (theophylline)
Theoclear LA-260 (theophylline)
Theoclear-80 (theophylline)
Theocon (guaifenesin / theophylline)
Theodrine (ephedrine / phenobarbital / theophylline)
Theolair (theophylline)
Theolair-SR (theophylline)
Theolate (guaifenesin / theophylline)
Theomar GG (guaifenesin / theophylline)
Theomax DF (ephedrine / hydroxyzine / theophylline)
Theophyll-GG (guaifenesin / theophylline)
theophylline
Theophylline KI (potassium iodide / theophylline)
Theovent (theophylline)
Therapy Bayer (aspirin)
thiabendazole
tizanidine
topotecan
Treanda (bendamustine)
Trexall (methotrexate)
Tri-Buffered Aspirin (aspirin)
trovafloxacin
Trovan (trovafloxacin)
Truxophyllin (theophylline)
Uni Bronchial (guaifenesin / theophylline)
Uni-Dur (theophylline)
Uniphyl (theophylline)
Ursinus (aspirin / pseudoephedrine)
Valium (diazepam)
Valrelease (diazepam)
Vanquish (acetaminophen / aspirin / caffeine)
vemurafenib
Versacloz (clozapine)
VesPro Melatonin (melatonin)
Zanaflex (tizanidine)
Zaponex (clozapine)
Zelboraf (vemurafenib)
Zero-Order Release (aspirin)
Zetran (diazepam)
ZORprin (aspirin)
Check for interactions with caffeine
Type in a drug name and select a drug from the list.
You should also know about...
caffeine alcohol/food Interactions
There are 3 alcohol/food interactions with caffeine
caffeine disease Interactions
There are 3 disease interactions with caffeine which include:
See also...
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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